MMP16

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MMP16
Protein MMP16 PDB 1rm8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MMP16, C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metallopeptidase 16
External IDs MGI: 1276107 HomoloGene: 55939 GeneCards: MMP16
RNA expression pattern
PBB GE MMP16 208167 s at fs.png

PBB GE MMP16 207012 at fs.png

PBB GE MMP16 208166 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005941
NM_022564
NM_032297

NM_019724

RefSeq (protein)

NP_005932

NP_062698.2
NP_062698

Location (UCSC) Chr 8: 88.03 – 88.33 Mb Chr 4: 17.85 – 18.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.[3][4]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Takino T, Sato H, Shinagawa A, Seiki M (Nov 1995). "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family". J Biol Chem. 270 (39): 23013–20. doi:10.1074/jbc.270.39.23013. PMID 7559440. 
  4. ^ a b "Entrez Gene: MMP16 matrix metallopeptidase 16 (membrane-inserted)". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.016