MMP19

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MMP19
Identifiers
Aliases MMP19, MMP18, RASI-1, CODA, matrix metallopeptidase 19
External IDs MGI: 1927899 HomoloGene: 1820 GeneCards: MMP19
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032360
NM_001272101
NM_002429
NM_022790
NM_022792

NM_001164197
NM_021412

RefSeq (protein)

NP_001259030
NP_002420

NP_067387.1
NP_001157669
NP_067387

Location (UCSC) Chr 12: 55.84 – 55.84 Mb Chr 10: 128.79 – 128.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the MMP19 gene.[3][4]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and endothelial cells and it has a role in cellular proliferation, migration, angiogenesis and adhesion. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kolb C, Mauch S, Peter HH, Krawinkel U, Sedlacek R (Oct 1997). "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient". Immunol Lett. 57 (1–3): 83–8. doi:10.1016/S0165-2478(97)00057-6. PMID 9232430. 
  4. ^ a b "Entrez Gene: MMP19 matrix metallopeptidase 19". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.021