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Matrix metallopeptidase 21
Symbols MMP21 ; MMP-21
External IDs OMIM608416 MGI2664387 HomoloGene17519 GeneCards: MMP21 Gene
EC number 3.4.24.-
RNA expression pattern
PBB GE MMP21 gnf1h06009 at tn.png
More reference expression data
Species Human Mouse
Entrez 118856 214766
Ensembl ENSG00000154485 ENSMUSG00000030981
UniProt Q8N119 Q8K3F2
RefSeq (mRNA) NM_147191 NM_152944
RefSeq (protein) NP_671724 NP_694423
Location (UCSC) Chr 10:
125.77 – 125.78 Mb
Chr 7:
133.67 – 133.68 Mb
PubMed search [1] [2]

Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.[1][2]


This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.[2]


  1. ^ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011. 
  2. ^ a b "Entrez Gene: MMP21 matrix metallopeptidase 21". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.026