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AliasesMMP23B, MIFR, MIFR-1, MMP22, MMP23A, matrix metallopeptidase 23B
External IDsOMIM: 603321 MGI: 1347361 HomoloGene: 3424 GeneCards: MMP23B
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MMP23B
Genomic location for MMP23B
Band1p36.33Start1,632,095 bp[1]
End1,635,263 bp[1]
RNA expression pattern
PBB GE MMP23B 207118 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 1.63 – 1.64 MbChr 4: 155.65 – 155.65 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Matrix metalloproteinase-23 is an enzyme that in humans is encoded by the MMP23B gene.[5][6][7]


This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the copy of the duplicated region of the gene that is closer to the end of the chromosome (more telemeric).[7]

MMP23B is strongly expressed in ovary and heart.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189409 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029061 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Gururajan R, Grenet J, Lahti JM, Kidd VJ (May 1999). "Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3". Genomics. 52 (1): 101–6. doi:10.1006/geno.1998.5401. PMID 9740677.
  6. ^ Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ (Nov 1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2". Genome Res. 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781. PMID 9750192.
  7. ^ a b "Entrez Gene: MMP23B matrix metallopeptidase 23B".
  8. ^ Zhao S, Zhao Y, Niu P, Wang N, Tang Z, Zan L, Li K (2011). "Molecular characterization of porcine MMP19 and MMP23B genes and its association with immune traits". Int. J. Biol. Sci. 7 (8): 1101–13. doi:10.7150/ijbs.7.1101. PMC 3174387. PMID 21927579.

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.022