MMP25

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MMP25
Identifiers
AliasesMMP25, MMP-25, MMP20, MMP20A, MMPL1, MT-MMP 6, MT-MMP6, MT6-MMP, MT6MMP, MTMMP6, matrix metallopeptidase 25
External IDsOMIM: 608482 MGI: 2443938 HomoloGene: 23375 GeneCards: MMP25
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for MMP25
Genomic location for MMP25
Band16p13.3Start3,046,561 bp[1]
End3,060,726 bp[1]
RNA expression pattern
PBB GE MMP25 207289 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004142
NM_022468
NM_022718

NM_001033339
NM_001320258

RefSeq (protein)

NP_071913

NP_001028511
NP_001307187

Location (UCSC)Chr 16: 3.05 – 3.06 MbChr 17: 23.63 – 23.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene.[5][6][7]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000008516 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023903 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Pei D (Feb 2000). "Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage". Cell Res. 9 (4): 291–303. doi:10.1038/sj.cr.7290028. PMID 10628838.
  6. ^ Velasco G, Cal S, Merlos-Suarez A, Ferrando AA, Alvarez S, Nakano A, Arribas J, Lopez-Otin C (Mar 2000). "Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors". Cancer Res. 60 (4): 877–82. PMID 10706098.
  7. ^ a b "Entrez Gene: MMP25 matrix metallopeptidase 25".

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.024