MMP26

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MMP26
Identifiers
Aliases MMP26
External IDs HomoloGene: 49684 GeneCards: MMP26
RNA expression pattern
PBB GE MMP26 220541 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021801

n/a

RefSeq (protein)

NP_068573

n/a

Location (UCSC) Chr 11: 4.7 – 4.99 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Matrix metalloproteinase-26 also known as matrilysin-2 and endometase is an enzyme that in humans is encoded by the MMP26 gene.[2][3][4]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin (A1AT), alpha 2-macroglobulin (A2M), and insulin-like growth factor-binding protein 1 (IGFBP), and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Park HI, Ni J, Gerkema FE, Liu D, Belozerov VE, Sang QX (Aug 2000). "Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor". J Biol Chem. 275 (27): 20540–4. doi:10.1074/jbc.M002349200. PMID 10801841. 
  3. ^ de Coignac AB, Elson G, Delneste Y, Magistrelli G, Jeannin P, Aubry JP, Berthier O, Schmitt D, Bonnefoy JY, Gauchat JF (Jul 2000). "Cloning of MMP-26. A novel matrilysin-like proteinase". Eur J Biochem. 267 (11): 3323–9. doi:10.1046/j.1432-1327.2000.01363.x. PMID 10824119. 
  4. ^ a b "Entrez Gene: MMP26 matrix metallopeptidase 26". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.029