MMP28

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MMP28
Identifiers
Aliases MMP28, EPILYSIN, MM28, MMP-25, MMP-28, MMP25, matrix metallopeptidase 28
External IDs MGI: 2153062 HomoloGene: 41559 GeneCards: MMP28
RNA expression pattern
PBB GE MMP28 219909 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032278
NM_024302
NM_032950

NM_080453
NM_172797
NM_001320300

RefSeq (protein)

NP_001027449
NP_077278
NP_116568
NP_116568.1

n/a

Location (UCSC) Chr 17: 35.76 – 35.8 Mb Chr 11: 83.44 – 83.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Matrix metalloproteinase 28 also known as epilysin is an enzyme that in humans is encoded by the MMP28 gene.[3][4][5]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lohi J, Wilson CL, Roby JD, Parks WC (Mar 2001). "Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury". J Biol Chem. 276 (13): 10134–44. doi:10.1074/jbc.M001599200. PMID 11121398. 
  4. ^ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011. 
  5. ^ a b "Entrez Gene: MMP28 matrix metallopeptidase 28". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.030