MMP8

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MMP8
Protein MMP8 PDB 1a85.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MMP8, CLG1, HNC, MMP-8, PMNL-CL, matrix metallopeptidase 8
External IDs MGI: 1202395 HomoloGene: 22482 GeneCards: MMP8
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for MMP8
Genomic location for MMP8
Band 11q22.2 Start 102,711,795 bp[1]
End 102,727,050 bp[1]
RNA expression pattern
PBB GE MMP8 207329 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001304441
NM_001304442
NM_002424

NM_008611

RefSeq (protein)

NP_001291370
NP_001291371
NP_002415

NP_032637

Location (UCSC) Chr 11: 102.71 – 102.73 Mb Chr 11: 7.56 – 7.57 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals.[5] In humans, the MMP-8 protein is encoded by the MMP8 gene.[6][7]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118113 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005800 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: MMP8 matrix metallopeptidase 8 (neutrophil collagenase)". 
  6. ^ Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL (July 1990). "Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases". J. Biol. Chem. 265 (20): 11421–4. PMID 2164002. 
  7. ^ Devarajan P, Mookhtiar K, Van Wart H, Berliner N (June 1991). "Structure and expression of the cDNA encoding human neutrophil collagenase". Blood. 77 (12): 2731–8. PMID 1646048. 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.002