MN1 (gene)

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MN1
Identifiers
Aliases MN1, MGCR, MGCR1, MGCR1-PEN, dJ353E16.2, meningioma (disrupted in balanced translocation) 1, MN1 proto-oncogene, transcriptional regulator
External IDs MGI: 1261813 HomoloGene: 37620 GeneCards: MN1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002430

NM_001081235

RefSeq (protein)

NP_002421

NP_001074704.1
NP_001074704

Location (UCSC) Chr 22: 27.75 – 27.8 Mb Chr 5: 111.42 – 111.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter.[3] Its official full name is meningioma (disrupted in balanced translocation) 1 because it is disrupted by a balanced translocation (4;22) in a meningioma.

Function[edit]

MN1 is a transcription coregulator that enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300.[4] MN1 also acts as a coactivator of the vitamin D receptor.[5]

Clinical significance[edit]

Its inactivation may be part of the cause of certain meningiomas.[3] A potential link to leukemia[6] including acute myeloid leukemia[7] has also been described.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA (April 1995). "Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma". Oncogene. 10 (8): 1521–8. PMID 7731706. 
  4. ^ van Wely KH, Molijn AC, Buijs A, Meester-Smoor MA, Aarnoudse AJ, Hellemons A, den Besten P, Grosveld GC, Zwarthoff EC (February 2003). "The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription". Oncogene. 22 (5): 699–709. doi:10.1038/sj.onc.1206124. PMID 12569362. 
  5. ^ Sutton AL, Zhang X, Ellison TI, Macdonald PN (September 2005). "The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation". Mol. Endocrinol. 19 (9): 2234–44. doi:10.1210/me.2005-0081. PMID 15890672. 
  6. ^ Buijs A, Sherr S, van Baal S, et al. (April 1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8): 1511–9. PMID 7731705. 
  7. ^ Grosveld GC (2007). "MN1, a novel player in human AML". Blood Cells Mol. Dis. 39 (3): 336–9. doi:10.1016/j.bcmd.2007.06.009. PMC 2387274Freely accessible. PMID 17698380. 

Further reading[edit]