MNT (gene)

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MAX network transcriptional repressor
Symbols MNT ; MAD6; MXD6; ROX; bHLHd3
External IDs OMIM603039 MGI109150 HomoloGene7842 GeneCards: MNT Gene
RNA expression pattern
PBB GE MNT 204206 at tn.png
More reference expression data
Species Human Mouse
Entrez 4335 17428
Ensembl ENSG00000070444 ENSMUSG00000000282
UniProt Q99583 O08789
RefSeq (mRNA) NM_020310 NM_010813
RefSeq (protein) NP_064706 NP_034943
Location (UCSC) Chr 17:
2.38 – 2.4 Mb
Chr 11:
74.83 – 74.85 Mb
PubMed search [1] [2]

Max-binding protein MNT is a protein that in humans is encoded by the MNT gene.[1][2]


The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.[2]


MNT (gene) has been shown to interact with MLX,[3][4] SIN3A[5] and MAX.[5]


  1. ^ Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (Apr 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics 49 (2): 275–82. doi:10.1006/geno.1998.5241. PMID 9598315. 
  2. ^ a b "Entrez Gene: MNT MAX binding protein". 
  3. ^ Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (Mar 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181. 
  4. ^ Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (Jul 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583. 
  5. ^ a b Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.