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- (M)ustargen (also known as mechlorethamine, chlormethine, mustine, nitrogen mustard, or MSD)
- (O)ncovin (also known as Vincristine or VCR)
- (P)rocarbazine (also known as Matulane or Natulan)
- (P)rednisone (also known as Deltasone or Orasone)
The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin's lymphoma treatment is ABVD.
|(M)ustargen||6 mg/m²||IV bolus||Days 1 and 8|
|(O)ncovin||1.4 mg/m² (max. 2 mg)||IV bolus||Days 1 and 8|
|(P)rocarbazine||100 mg/m²||PO qd||Days 1-14|
|(P)rednisone||40 mg/m²||PO qd||Days 1-14|
There is 20% chance of developing a second cancer within 20 years of MOPP treatment. As a result, MOPP is rarely used any more for treatment for Hodgkin's. MOPP has been known to cause alopecia (hair loss) and skin sensitivity (especially to sunlight). Nausea, vomiting, and stomachache are common, as are chills, constipation, and frequent urination. Permanent sterility is a frequent side effect.