MPP6

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MPP6
Identifiers
AliasesMPP6, PALS2, VAM-1, VAM1, p55T, membrane palmitoylated protein 6
External IDsMGI: 1927340 HomoloGene: 22976 GeneCards: MPP6
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MPP6
Genomic location for MPP6
Band7p15.3Start24,573,268 bp[1]
End24,694,193 bp[1]
RNA expression pattern
PBB GE MPP6 205429 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303037
NM_016447

RefSeq (protein)

NP_001289966
NP_057531

NP_001158205
NP_001158206
NP_064323
NP_001348176
NP_001348177

Location (UCSC)Chr 7: 24.57 – 24.69 MbChr 6: 50.11 – 50.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.[5][6][7]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001).[supplied by OMIM][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105926 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038388 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959. 
  6. ^ Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936. 
  7. ^ a b "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)". 

Further reading[edit]