MRPL1

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MRPL1
PBB Protein MRPL11 image.jpg
Identifiers
AliasesMRPL1, BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1
External IDsOMIM: 611821 MGI: 2137202 HomoloGene: 41355 GeneCards: MRPL1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for MRPL1
Genomic location for MRPL1
Band4q21.1Start77,862,830 bp[1]
End77,952,785 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020236

NM_001039084
NM_053158

RefSeq (protein)

NP_064621

NP_001034173
NP_444388

Location (UCSC)Chr 4: 77.86 – 77.95 MbChr 5: 96.21 – 96.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169288 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029486 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPL1 mitochondrial ribosomal protein L1".

Further reading[edit]