MRPL1

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MRPL1
PBB Protein MRPL11 image.jpg
Identifiers
Aliases MRPL1, BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1
External IDs MGI: 2137202 HomoloGene: 41355 GeneCards: MRPL1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020236

NM_001039084
NM_053158

RefSeq (protein)

NP_064621

NP_444388.2
NP_001034173
NP_444388

Location (UCSC) Chr 4: 77.86 – 77.95 Mb Chr 5: 96.21 – 96.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.[3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.[3]

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