MRPL10

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MRPL10
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL10, L10MT, MRP-L10, MRP-L8, MRPL8, RPML8, mitochondrial ribosomal protein L10
External IDs MGI: 1333801 HomoloGene: 41665 GeneCards: MRPL10
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145255
NM_148887

NM_026154

RefSeq (protein)

NP_660298
NP_683685

NP_080430.1
NP_080430

Location (UCSC) Chr 17: 47.82 – 47.83 Mb Chr 11: 97.04 – 97.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene.[3][4]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941. 
  4. ^ a b "Entrez Gene: MRPL10 mitochondrial ribosomal protein L10". 

Further reading[edit]