MRPL15

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MRPL15
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL15, L15mt, MRP-L15, MRP-L7, RPML7, HSPC145, mitochondrial ribosomal protein L15
External IDs MGI: 1351639 HomoloGene: 32210 GeneCards: MRPL15
RNA expression pattern
PBB GE MRPL15 218027 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014175

NM_001177658
NM_025300

RefSeq (protein)

NP_054894

NP_001171129.1
NP_079576.1
NP_001171129
NP_079576

Location (UCSC) Chr 8: 54.14 – 54.15 Mb Chr 1: 4.77 – 4.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.[3][4]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634. 
  4. ^ a b "Entrez Gene: MRPL15 mitochondrial ribosomal protein L15". 

Further reading[edit]