MRPL20

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MRPL20
PBB Protein MRPL11 image.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20
External IDsMGI: 2137221 HomoloGene: 9941 GeneCards: MRPL20
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MRPL20
Genomic location for MRPL20
Band1p36.33Start1,401,909 bp[1]
End1,407,293 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017971
NM_001318485

NM_025570

RefSeq (protein)

NP_001305414
NP_060441

NP_079846

Location (UCSC)Chr 1: 1.4 – 1.41 MbChr 4: 155.8 – 155.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242485 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029066 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: MRPL20 mitochondrial ribosomal protein L20".

Further reading[edit]