MRPL20

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MRPL20
PBB Protein MRPL11 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20
External IDs MGI: 2137221 HomoloGene: 9941 GeneCards: MRPL20
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017971
NM_001318485

NM_025570

RefSeq (protein)

NP_001305414
NP_060441

NP_079846.1
NP_079846

Location (UCSC) Chr 1: 1.4 – 1.41 Mb Chr 4: 155.8 – 155.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.[3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.[3]

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