MRPL24

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MRPL24
PBB Protein MRPL11 image.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL24, L24mt, MRP-L18, MRP-L24, mitochondrial ribosomal protein L24
External IDsOMIM: 611836 MGI: 1914957 HomoloGene: 12241 GeneCards: MRPL24
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MRPL24
Genomic location for MRPL24
Band1q23.1Start156,737,303 bp[1]
End156,741,590 bp[1]
RNA expression pattern
PBB GE MRPL24 218270 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024540
NM_145729

NM_026591

RefSeq (protein)

NP_078816
NP_663781

NP_080867

Location (UCSC)Chr 1: 156.74 – 156.74 MbChr 3: 87.92 – 87.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its Escherichia coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143314 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019710 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPL24 mitochondrial ribosomal protein L24".

Further reading[edit]