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Available structures
PDB Ortholog search: PDBe RCSB
Aliases MRPL28, MAAT1, p15, mitochondrial ribosomal protein L28
External IDs MGI: 1915861 HomoloGene: 4693 GeneCards: MRPL28
RNA expression pattern
PBB GE MRPL28 204599 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 16: 0.37 – 0.37 Mb Chr 17: 26.12 – 26.13 Mb
PubMed search [1] [2]
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39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.[3][3][4][4][5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Robbins PF, el-Gamil M, Li YF, Topalian SL, Rivoltini L, Sakaguchi K, Appella E, Kawakami Y, Rosenberg SA (Jun 1995). "Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes". J Immunol. 154 (11): 5944–50. PMID 7751637. 
  4. ^ a b Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941. 
  5. ^ a b "Entrez Gene: MRPL28 mitochondrial ribosomal protein L28". 

Further reading[edit]