MRPL30

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MRPL30
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL30, L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28, mitochondrial ribosomal protein L30
External IDs MGI: 1333820 HomoloGene: 32675 GeneCards: MRPL30
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016503
NM_145212
NM_145213

NM_027098

RefSeq (protein)

NP_660213

NP_081374.1
NP_081374

Location (UCSC) Chr 2: 99.18 – 99.2 Mb Chr 1: 37.89 – 37.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene.[3]

Function[edit]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified at least two transcript variants encoding the same protein. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p.[3]

References[edit]

Further reading[edit]