MRPL33

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MRPL33
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL33, C2orf1, L33mt, MRP-L33, RPL33L, mitochondrial ribosomal protein L33
External IDs MGI: 2137225 HomoloGene: 81733 GeneCards: MRPL33
RNA expression pattern
PBB GE MRPL33 203781 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145330
NM_004891

NM_025796

RefSeq (protein)

NP_004882
NP_663303

NP_080072.2
NP_080072

Location (UCSC) Chr 2: 27.77 – 27.99 Mb Chr 5: 31.6 – 31.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.[3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.[3]

References[edit]

Further reading[edit]