MRPL4

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MRPL4
PBB Protein MRPL11 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL4, CGI-28, L4mt, mitochondrial ribosomal protein L4
External IDs MGI: 2137210 HomoloGene: 32286 GeneCards: MRPL4
RNA expression pattern
PBB GE MRPL4 218105 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015956
NM_146387
NM_146388

NM_023167

RefSeq (protein)

NP_057040
NP_666499
NP_666500
NP_057040.2
NP_666499.1

NP_075656.2
NP_075656

Location (UCSC) Chr 19: 10.25 – 10.26 Mb Chr 9: 21 – 21.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene.[3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms.[3]

References[edit]

Further reading[edit]