MRPS12

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MRPS12
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS12, MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12, mitochondrial ribosomal protein S12
External IDs MGI: 1346333 HomoloGene: 6848 GeneCards: MRPS12
RNA expression pattern
PBB GE MRPS12 204331 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033363
NM_021107
NM_033362

NM_011885

RefSeq (protein)

NP_066930
NP_203526
NP_203527

NP_036015.1
NP_036015

Location (UCSC) Chr 19: 38.93 – 38.93 Mb Chr 7: 28.74 – 28.74 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S12, mitochondrial is a protein that in humans is encoded by the MRPS12 gene.[3][4][5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT (Jun 1998). "Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus". Genomics. 48 (3): 384–8. doi:10.1006/geno.1997.5166. PMID 9545647. 
  4. ^ Johnson DF, Hamon M, Fischel-Ghodsian N (Dec 1998). "Characterization of the human mitochondrial ribosomal S12 gene". Genomics. 52 (3): 363–8. doi:10.1006/geno.1998.5448. PMID 9790755. 
  5. ^ a b "Entrez Gene: MRPS12 mitochondrial ribosomal protein S12". 

Further reading[edit]