MRPS17

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MRPS17
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS17, HSPC011, MRP-S17, RPMS17, S17mt, mitochondrial ribosomal protein S17
External IDsMGI: 1913508 HomoloGene: 9320 GeneCards: MRPS17
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MRPS17
Genomic location for MRPS17
Band7p11.2Start55,951,877 bp[1]
End55,956,500 bp[1]
RNA expression pattern
PBB GE MRPS17 218982 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015969

NM_025450

RefSeq (protein)

NP_057053

Location (UCSC)Chr 7: 55.95 – 55.96 MbChr 5: 129.72 – 129.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S17, mitochondrial is a protein that in humans is encoded by the MRPS17 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000239789 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034211 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. ^ a b "Entrez Gene: MRPS17 mitochondrial ribosomal protein S17".

Further reading[edit]