MRPS22

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MRPS22
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS22, C3orf5, COXPD5, GIBT, MRP-S22, RPMS22, GK002, mitochondrial ribosomal protein S22
External IDs MGI: 1928137 HomoloGene: 57030 GeneCards: MRPS22
RNA expression pattern
PBB GE MRPS22 219220 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020191

NM_025485

RefSeq (protein)

NP_064576

NP_079761.1
NP_079761

Location (UCSC) Chr 3: 139.01 – 139.36 Mb Chr 9: 98.59 – 98.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.[3][4]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A, Pilia G (Feb 2001). "The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome". Nat Genet. 27 (2): 159–66. doi:10.1038/84781. PMID 11175783. 
  4. ^ a b "Entrez Gene: MRPS22 mitochondrial ribosomal protein S22". 

Further reading[edit]