MRPS22

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MRPS22
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS22, C3orf5, COXPD5, GIBT, MRP-S22, RPMS22, GK002, mitochondrial ribosomal protein S22
External IDsMGI: 1928137 HomoloGene: 57030 GeneCards: MRPS22
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MRPS22
Genomic location for MRPS22
Band3q23Start139,005,806 bp[1]
End139,357,223 bp[1]
RNA expression pattern
PBB GE MRPS22 219220 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020191
NM_001363857
NM_001363893

NM_025485

RefSeq (protein)

NP_064576
NP_001350786
NP_001350822

NP_079761

Location (UCSC)Chr 3: 139.01 – 139.36 MbChr 9: 98.59 – 98.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175110 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032459 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A, Pilia G (Feb 2001). "The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome". Nat Genet. 27 (2): 159–66. doi:10.1038/84781. PMID 11175783.
  6. ^ a b "Entrez Gene: MRPS22 mitochondrial ribosomal protein S22".

Further reading[edit]