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Available structures
PDBOrtholog search: PDBe RCSB
AliasesMRPS24, MRP-S24, S24mt, bMRP-47, bMRP47, HSPC335, mitochondrial ribosomal protein S24
External IDsMGI: 1928142 HomoloGene: 57043 GeneCards: MRPS24
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MRPS24
Genomic location for MRPS24
Band7p13Start43,866,558 bp[1]
End43,869,893 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 43.87 – 43.87 MbChr 11: 5.7 – 5.72 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene.[5][6][7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000062582 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020477 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Xu L, He GP, Li A, Ro HS (Apr 1994). "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs". Nucleic Acids Res. 22 (4): 646–55. doi:10.1093/nar/22.4.646. PMC 307856. PMID 8127713.
  6. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  7. ^ a b "Entrez Gene: MRPS24 mitochondrial ribosomal protein S24".

Further reading[edit]