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Available structures
PDBOrtholog search: PDBe RCSB
AliasesMRPS26, C20orf193, GI008, MRP-S13, MRP-S26, MRPS13, NY-BR-87, RPMS13, dJ534B8.3, mitochondrial ribosomal protein S26
External IDsMGI: 1333830 HomoloGene: 12778 GeneCards: MRPS26
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for MRPS26
Genomic location for MRPS26
Band20p13Start3,046,052 bp[1]
End3,048,250 bp[1]
RNA expression pattern
PBB GE MRPS26 gnf1h00455 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 20: 3.05 – 3.05 MbChr 2: 130.56 – 130.57 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

28S ribosomal protein S26, mitochondrial is a protein that in humans is encoded by the MRPS26 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125901 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037740 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  6. ^ a b "Entrez Gene: MRPS26 mitochondrial ribosomal protein S26".

Further reading[edit]