MRPS30

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MRPS30
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS30, MRP-S30, PAP, PDCD9, S30mt, mitochondrial ribosomal protein S30
External IDs MGI: 1926237 HomoloGene: 9607 GeneCards: MRPS30
RNA expression pattern
PBB GE MRPS30 218398 at fs.png

PBB GE MRPS30 222275 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016640

NM_021556

RefSeq (protein)

NP_057724

NP_067531.1
NP_067531

Location (UCSC) Chr 5: 44.81 – 44.82 Mb Chr 13: 118.38 – 118.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.[3][4][5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Carim L, Sumoy L, Nadal M, Estivill X, Escarceller M (May 2000). "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52". Cytogenet Cell Genet. 87 (1–2): 85–8. doi:10.1159/000015397. PMID 10640817. 
  4. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123. 
  5. ^ a b "Entrez Gene: MRPS30 mitochondrial ribosomal protein S30". 

Further reading[edit]