From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases MRPS30, MRP-S30, PAP, PDCD9, S30mt, mitochondrial ribosomal protein S30
External IDs MGI: 1926237 HomoloGene: 9607 GeneCards: MRPS30
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for MRPS30
Genomic location for MRPS30
Band 5p12 Start 44,808,925 bp[1]
End 44,820,428 bp[1]
RNA expression pattern
PBB GE MRPS30 218398 at fs.png

PBB GE MRPS30 222275 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 44.81 – 44.82 Mb Chr 13: 118.38 – 118.39 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.[5][6][7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112996 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021731 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Carim L, Sumoy L, Nadal M, Estivill X, Escarceller M (May 2000). "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52". Cytogenet Cell Genet. 87 (1–2): 85–8. doi:10.1159/000015397. PMID 10640817. 
  6. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123. 
  7. ^ a b "Entrez Gene: MRPS30 mitochondrial ribosomal protein S30". 

Further reading[edit]