MRPS35

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MRPS35
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS35, MDS023, MRP-S28, MRPS28, HDCMD11P, mitochondrial ribosomal protein S35
External IDs MGI: 2385255 HomoloGene: 11048 GeneCards: MRPS35
RNA expression pattern
PBB GE MRPS35 217942 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021821
NM_001190864

NM_145573

RefSeq (protein)

NP_001177793
NP_068593

NP_663548.2
NP_663548

Location (UCSC) Chr 12: 27.71 – 27.76 Mb Chr 6: 147.04 – 147.07 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene.[3][4]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123. 
  4. ^ a b "Entrez Gene: MRPS35 mitochondrial ribosomal protein S35". 

Further reading[edit]