MRPS6

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MRPS6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS6, C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6
External IDsMGI: 2153111 HomoloGene: 41871 GeneCards: MRPS6
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for MRPS6
Genomic location for MRPS6
Band21q22.11Start34,073,224 bp[1]
End34,143,034 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032476

NM_080456

RefSeq (protein)

NP_115865

NP_536704

Location (UCSC)Chr 21: 34.07 – 34.14 MbChr 16: 92.06 – 92.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243927 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039680 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

Further reading[edit]