MRPS7

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MRPS7
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS7, MRP-S, MRP-S7, RP-S7, RPMS7, S7mt, bMRP27a, mitochondrial ribosomal protein S7
External IDs MGI: 1354367 HomoloGene: 9321 GeneCards: MRPS7
RNA expression pattern
PBB GE MRPS7 217932 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015971

NM_025305

RefSeq (protein)

NP_057055

NP_079581.1
NP_079581

Location (UCSC) Chr 17: 75.26 – 75.27 Mb Chr 11: 115.6 – 115.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.[3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p.[3]

References[edit]

Further reading[edit]