MSC (gene)

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MSC
Identifiers
Aliases MSC, ABF-1, ABF1, MYOR, bHLHa22, musculin
External IDs MGI: 1333884 HomoloGene: 3738 GeneCards: MSC
RNA expression pattern
PBB GE MSC 209928 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005098

NM_010827

RefSeq (protein)

NP_005089

NP_034957.1
NP_034957

Location (UCSC) Chr 8: 71.84 – 71.84 Mb Chr 1: 14.75 – 14.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Musculin is a protein that in humans is encoded by the MSC gene.[3][4][5]

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C (Jun 1998). "Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes". Mol Cell Biol. 18 (6): 3130–9. PMC 108895Freely accessible. PMID 9584154. 
  4. ^ Robb L, Brodnicki T, Copeland NG, Gilbert DJ, Jenkins NA, Harvey RP (May 1999). "Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1". Genomics. 57 (2): 318–9. doi:10.1006/geno.1999.5764. PMID 10198176. 
  5. ^ a b "Entrez Gene: MSC musculin (activated B-cell factor-1)". 

Further reading[edit]