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MutS homolog 4
Symbol MSH4
External IDs OMIM602105 MGI1860077 HomoloGene1830 GeneCards: MSH4 Gene
RNA expression pattern
PBB GE MSH4 210533 at tn.png
More reference expression data
Species Human Mouse
Entrez 4438 55993
Ensembl ENSG00000057468 ENSMUSG00000005493
UniProt O15457 Q99MT2
RefSeq (mRNA) NM_002440 NM_001282054
RefSeq (protein) NP_002431 NP_001268983
Location (UCSC) Chr 1:
76.26 – 76.38 Mb
Chr 3:
153.86 – 153.91 Mb
PubMed search [1] [2]

MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene.[1][2]


MSH4 has been shown to interact with MLH1,[3] MSH5[4][5][6] and MLH3.[7]


  1. ^ Paquis-Flucklinger V, Santucci-Darmanin S, Paul R, Saunieres A, Turc-Carel C, Desnuelle C (December 1997). "Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene". Genomics 44 (2): 188–94. doi:10.1006/geno.1997.4857. PMID 9299235. 
  2. ^ "Entrez Gene: MSH4 mutS homolog 4 (E. coli)". 
  3. ^ Santucci-Darmanin, S; Walpita D; Lespinasse F; Desnuelle C; Ashley T; Paquis-Flucklinger V (August 2000). "MSH4 acts in conjunction with MLH1 during mammalian meiosis". FASEB J. (UNITED STATES) 14 (11): 1539–47. doi:10.1096/fj.14.11.1539. ISSN 0892-6638. PMID 10928988. 
  4. ^ Her, Chengtao; Wu Xiling; Griswold Michael D; Zhou Feng (February 2003). "Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1". Cancer Res. (United States) 63 (4): 865–72. ISSN 0008-5472. PMID 12591739. 
  5. ^ Winand, N J; Panzer J A; Kolodner R D (October 1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene". Genomics (UNITED STATES) 53 (1): 69–80. doi:10.1006/geno.1998.5447. ISSN 0888-7543. PMID 9787078. 
  6. ^ Bocker, T; Barusevicius A, Snowden T, Rasio D, Guerrette S, Robbins D, Schmidt C, Burczak J, Croce C M, Copeland T, Kovatich A J, Fishel R (February 1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis". Cancer Res. (UNITED STATES) 59 (4): 816–22. ISSN 0008-5472. PMID 10029069. 
  7. ^ Santucci-Darmanin, Sabine; Neyton Sophie, Lespinasse Françoise, Saunières Anne, Gaudray Patrick, Paquis-Flucklinger Véronique (July 2002). "The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination". Hum. Mol. Genet. (England) 11 (15): 1697–706. doi:10.1093/hmg/11.15.1697. ISSN 0964-6906. PMID 12095912. 

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