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Macrophage stimulating 1 receptor
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MST1R ; CD136; CDw136; PTK8; RON
External IDs OMIM600168 MGI99614 HomoloGene1835 ChEMBL: 2689 GeneCards: MST1R Gene
EC number
RNA expression pattern
PBB GE MST1R 205455 at tn.png
More reference expression data
Species Human Mouse
Entrez 4486 19882
Ensembl ENSG00000164078 ENSMUSG00000032584
UniProt Q04912 Q62190
RefSeq (mRNA) NM_001244937 NM_001287261
RefSeq (protein) NP_001231866 NP_001274190
Location (UCSC) Chr 3:
49.89 – 49.9 Mb
Chr 9:
107.91 – 107.92 Mb
PubMed search [1] [2]

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.[1][2] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.[1][3]


MST1R has been shown to interact with Grb2.[4][5]


  1. ^ a b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene 8 (5): 1195–202. PMID 8386824. 
  2. ^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)". 
  3. ^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829. 
  4. ^ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076. 
  5. ^ Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464. 

Further reading[edit]