MST1R

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MST1R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMST1R, CD136, CDw136, PTK8, RON, macrophage stimulating 1 receptor, NPCA3
External IDsMGI: 99614 HomoloGene: 1835 GeneCards: MST1R
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MST1R
Genomic location for MST1R
Band3p21.31Start49,887,002 bp[1]
End49,903,873 bp[1]
RNA expression pattern
PBB GE MST1R 205455 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001244937
NM_002447
NM_001318913

NM_001287261
NM_009074

RefSeq (protein)

NP_001231866
NP_001305842
NP_002438

NP_001274190
NP_033100

Location (UCSC)Chr 3: 49.89 – 49.9 MbChr 9: 107.91 – 107.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.[5][6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.[5][7]

Interactions[edit]

MST1R has been shown to interact with Grb2.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164078 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032584 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195–202. PMID 8386824. 
  6. ^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)". 
  7. ^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. PMC 395256Freely accessible. PMID 8062829. 
  8. ^ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076. 
  9. ^ Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. PMC 452340Freely accessible. PMID 8918464. 

Further reading[edit]