MT-ATP8

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ATP synthase F0 subunit 8
Identifiers
Symbols ATP8 ; ATPase8; MTATP8
External IDs OMIM516070 HomoloGene124425 GeneCards: ATP8 Gene
Orthologs
Species Human Mouse
Entrez 4509 n/a
Ensembl ENSG00000228253 n/a
UniProt P03928 n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr MT:
0.01 – 0.01 Mb
n/a
PubMed search [1] n/a
The 46-nucleotide overlap in the reading frames of the human mitochondrial genes MT-ATP8 and MT-ATP6. For each nucleotide triplet (square brackets), the corresponding amino acid is given (one-letter code), either in the +1 frame for MT-ATP8 (in red) or in the +3 frame for MT-ATP6 (in blue).
ATP synthase protein 8 (metazoa)
Identifiers
Symbol ATP-synt_8
Pfam PF00895
Pfam clan CL0255
InterPro IPR001421
Plant ATP synthase F0 subunit 8
Identifiers
Symbol YMF19
Pfam PF02326
Pfam clan CL0255
InterPro IPR003319
Fungal ATP synthase protein 8 (A6L)
Identifiers
Symbol Fun_ATP-synt_8
Pfam PF05933
Pfam clan CL0255
InterPro IPR009230

The protein[edit]

ATP synthase protein 8 is a subunit of mitochondrial ATP synthase.

This protein subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases.[1] The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa.

Subunit 8 differs in sequence between Metazoa, plants and Fungi.

The gene[edit]

The ATP synthase protein 8 of human and other mammals is encoded in the mitochondrial genome by the MT-ATP8 gene. When the complete human mitochondrial genome was first published, the MT-ATP8 gene was described as the unidentified reading frame URF A6L.[2]

An unusual feature of the MT-ATP8 gene is its 46-nucleotide overlap with the MT-ATP6 gene. With respect to the reading frame (+1) of MT-ATP8, the MT-ATP6 gene starts on the +3 reading frame.



References[edit]

  1. ^ Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ (May 2003). "The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification". J. Biol. Chem. 278 (20): 17867–75. doi:10.1074/jbc.M300967200. PMID 12626501. 
  2. ^ Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (April 1981). "Sequence and organization of the human mitochondrial genome". Nature 290 (5806): 457–65. doi:10.1038/290457a0. PMID 7219534. 

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR001421