MTCH1

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MTCH1
Identifiers
Aliases MTCH1, CGI-64, PIG60, PSAP, SLC25A49, mitochondrial carrier 1
External IDs MGI: 1929261 HomoloGene: 22807 GeneCards: MTCH1
RNA expression pattern
PBB GE MTCH1 221619 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271641
NM_014341

NM_019880
NM_001347335

RefSeq (protein)

NP_001258570
NP_055156

NP_063933.1
NP_001334264
NP_063933

Location (UCSC) Chr 6: 36.97 – 36.99 Mb Chr 17: 29.33 – 29.35 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial carrier homolog 1 (MTCH1), also referred to as presenilin 1-associated protein (PSAP), is a protein that in humans is encoded by the MTCH1 gene on chromosome 6.[3][4][5] MTCH1 is a proapoptotic mitochondrial protein potentially involved in Alzheimer’s disease (AD).[4][5][6]

Structure[edit]

The protein encoded by this gene is named for its structural resemblance to the members of the mitochondrial carrier protein family.[3][5] The MTCH1 gene contains 12 exons and produces four isoforms. These isoforms arise from alternative splicing of exon 8 and two potential start codons, which results in the deletion of 17 amino acid residues in the hydrophilic loop between two transmembrane domains of some isoforms.[7][8] Though they differ in sequence and length, the four isoforms still share a similar topological structure, including six transmembrane domains, one of which is responsible for localization to the outer mitochondrial membrane (OMM), and two N-terminal apoptotic domains. As a result, all four isoforms retain these apoptotic domains and mitochondrial localization, both of which are required for the protein’s proapoptotic function.[5][7][8]

Function[edit]

MTCH1 is a proapoptotic protein that localizes to the OMM and induces apoptosis independently of BAX and BAK.[4][5] One possible mechanism proposes that its interactions with the mitochondrial permeability transition pore (MPTP) complex leads to depolarization of the mitochondrial membrane, release of cytochrome C, and activation of caspase-3.[3][5] Expression of this protein is observed in 16 different tissue types, indicating that the protein may serve a housekeeping function.[8]

Clinical Significance[edit]

MTCH1 may be associated with AD and other neurodegenerative and neuroinflammatory diseases through its close interaction with presenilin.[3][6] However, more research is required to confirm its clinical involvement.[6]

Interactions[edit]

MTCH1 has been shown to interact with PS1.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c d e Xu X, Shi YC, Gao W, Mao G, Zhao G, Agrawal S, Chisolm GM, Sui D, Cui MZ (Dec 2002). "The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein". J Biol Chem. 277 (50): 48913–48922. doi:10.1074/jbc.M209613200. PMID 12377771. 
  4. ^ a b c "Entrez Gene: MTCH1 mitochondrial carrier homolog 1 (C. elegans)". 
  5. ^ a b c d e f Lamarca, V; Marzo, I; Sanz-Clemente, A; Carrodeguas, JA (May 2008). "Exposure of any of two proapoptotic domains of presenilin 1-associated protein/mitochondrial carrier homolog 1 on the surface of mitochondria is sufficient for induction of apoptosis in a Bax/Bak-independent manner.". European journal of cell biology. 87 (5): 325–34. doi:10.1016/j.ejcb.2008.02.004. PMID 18375015. 
  6. ^ a b c Vural, B; Sehitoğlu, E; Cavuş, F; Yalçınkaya, N; Haytural, H; Küçükerden, M; Ulusoy, C; Uğurel, E; Turan, S; Bulut, L; Türkoğlu, R; Shugaiv, E; Kürtüncü, M; Atakan, S; Güre, AO; Gül, A; Eraksoy, M; Akman-Demir, G; Tüzün, E (15 October 2013). "Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease.". Journal of Neuroimmunology. 263 (1-2): 139–44. doi:10.1016/j.jneuroim.2013.08.007. PMID 24035008. 
  7. ^ a b Mao, G; Tan, J; Gao, W; Shi, Y; Cui, MZ; Xu, X (April 2008). "Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP.". Biochimica et Biophysica Acta. 1780 (4): 696–708. doi:10.1016/j.bbagen.2008.01.013. PMID 18291114. 
  8. ^ a b c Lamarca, V; Sanz-Clemente, A; Pérez-Pé, R; Martínez-Lorenzo, MJ; Halaihel, N; Muniesa, P; Carrodeguas, JA (October 2007). "Two isoforms of PSAP/MTCH1 share two proapoptotic domains and multiple internal signals for import into the mitochondrial outer membrane.". American Journal of Physiology. Cell Physiology. 293 (4): C1347–61. doi:10.1152/ajpcell.00431.2006. PMID 17670888. 

Further reading[edit]