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Metal-regulatory transcription factor 1
Symbols MTF1 ; MTF-1; ZRF
External IDs OMIM600172 MGI101786 HomoloGene4347 GeneCards: MTF1 Gene
RNA expression pattern
PBB GE MTF1 205323 s at tn.png
PBB GE MTF1 205322 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4520 17764
Ensembl ENSG00000188786 ENSMUSG00000028890
UniProt Q14872 Q07243
RefSeq (mRNA) NM_005955 NM_008636
RefSeq (protein) NP_005946 NP_032662
Location (UCSC) Chr 1:
37.81 – 37.86 Mb
Chr 4:
124.8 – 124.85 Mb
PubMed search [1] [2]

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[1][2]

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[2]


  1. ^ Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W (Sep 1994). "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1". Nucleic Acids Res 22 (15): 3167–73. doi:10.1093/nar/22.15.3167. PMC 310292. PMID 8065932. 
  2. ^ a b "Entrez Gene: MTF1 metal-regulatory transcription factor 1". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.