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Available structures
PDB Ortholog search: PDBe RCSB
Aliases MTIF2, mitochondrial translational initiation factor 2
External IDs MGI: 1924034 HomoloGene: 1840 GeneCards: MTIF2
RNA expression pattern
PBB GE MTIF2 203095 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 2: 55.24 – 55.27 Mb Chr 11: 29.53 – 29.55 Mb
PubMed search [1] [2]
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Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.[3][4][5]

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bonner DS, Wiley JE, Farwell MA (Mar 1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids". Cytogenet Cell Genet. 83 (1–2): 80–1. doi:10.1159/000015133. PMID 9925935. 
  4. ^ Ma L, Spremulli LL (Feb 1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA". J Biol Chem. 270 (4): 1859–65. doi:10.1074/jbc.270.4.1859. PMID 7829522. 
  5. ^ a b "Entrez Gene: MTIF2 mitochondrial translational initiation factor 2". 

Further reading[edit]