MX1

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MX1
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases MX1, IFI-78K, IFI78, MX, MxA, MX dynamin like GTPase 1
External IDs HomoloGene: 1844 GeneCards: 4599
RNA expression pattern
PBB GE MX1 202086 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144925
NM_001178046
NM_001282920
NM_002462

n/a

RefSeq (protein)

NP_001138397.1
NP_001171517.1
NP_001269849.1
NP_002453.2

n/a

Location (UCSC) Chr 21: 41.42 – 41.46 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.[1][2]

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases.[2]

References[edit]

  1. ^ Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie 89 (6–7): 812–8. doi:10.1016/j.biochi.2007.04.015. PMID 17570575. 
  2. ^ a b "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". 

Further reading[edit]