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MX dynamin-like GTPase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MX1 ; IFI-78K; IFI78; MX; MxA
External IDs OMIM147150 MGI97244 HomoloGene1844 GeneCards: MX1 Gene
RNA expression pattern
PBB GE MX1 202086 at tn.png
More reference expression data
Species Human Mouse
Entrez 4599 17858
Ensembl ENSG00000157601 ENSMUSG00000023341
UniProt P20591 Q61924
RefSeq (mRNA) NM_001144925 NM_013606
RefSeq (protein) NP_001138397 NP_038634
Location (UCSC) Chr 21:
41.42 – 41.46 Mb
Chr 16:
97.69 – 97.72 Mb
PubMed search [1] [2]

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.[1][2]

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases.[2]


  1. ^ Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie 89 (6–7): 812–8. doi:10.1016/j.biochi.2007.04.015. PMID 17570575. 
  2. ^ a b "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". 

Further reading[edit]