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Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesMX2, MXB, MX dynamin like GTPase 2
External IDsHomoloGene: 74299 GeneCards: MX2
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for MX2
Genomic location for MX2
Band21q22.3Start41,361,943 bp[1]
End41,409,390 bp[1]
RNA expression pattern
PBB GE MX2 204994 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 21: 41.36 – 41.41 Mbn/a
PubMed search[2]n/a
View/Edit Human

For the aircraft and other subjects see MX2 (disambiguation)

Interferon-induced GTP-binding protein Mx2 is a protein that in humans is encoded by the MX2 gene.[3][4][5]

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183486 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Aebi M, Fah J, Hurt N, Samuel CE, Thomis D, Bazzigher L, Pavlovic J, Haller O, Staeheli P (Feb 1990). "cDNA structures and regulation of two interferon-induced human Mx proteins". Mol Cell Biol. 9 (11): 5062–72. PMC 363658. PMID 2481229.
  4. ^ Melen K, Keskinen P, Ronni T, Sareneva T, Lounatmaa K, Julkunen I (Nov 1996). "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope". J Biol Chem. 271 (38): 23478–86. doi:10.1074/jbc.271.38.23478. PMID 8798556.
  5. ^ a b "Entrez Gene: MX2 myxovirus (influenza virus) resistance 2 (mouse)".

Further reading[edit]