MXD3

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MXD3
Identifiers
Aliases MXD3, BHLHC13, MAD3, MYX, MAX dimerization protein 3
External IDs MGI: 104987 HomoloGene: 32333 GeneCards: 83463
Genetically Related Diseases
Disease Name References
obesity
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031300
NM_001142935

NM_016662

RefSeq (protein)

NP_001136407.1
NP_112590.1
NP_112590.1

NP_057871.2

Location (UCSC) Chr 5: 177.3 – 177.31 Mb Chr 13: 55.33 – 55.33 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.[4][5]

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex.[5] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle.[6] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels.[7]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_9970&geneId=350342". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.". EMBO J. 14 (22): 5646–59. PMC 394680free to read. PMID 8521822. 
  5. ^ a b "Entrez Gene: MXD3 MAX dimerization protein 3". 
  6. ^ Fox EJ, Wright SC (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1.". Biochem J. 370 (1): 307–13. doi:10.1042/bj20021583. PMC 1223166free to read. PMID 12444919. 
  7. ^ Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells.". PLOS ONE. 7 (7): e38508. doi:10.1371/journal.pone.0038508. PMID 22808009.