MXD4

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MXD4
Identifiers
Aliases MXD4, MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
External IDs MGI: 104991 HomoloGene: 4712 GeneCards: 10608
RNA expression pattern
PBB GE MXD4 210778 s at tn.png

PBB GE MXD4 212346 s at tn.png

PBB GE MXD4 212347 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006454

NM_010753

RefSeq (protein)

NP_006445.1

n/a

Location (UCSC) Chr 4: 2.25 – 2.26 Mb Chr 5: 34.17 – 34.19 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[1][2]

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[2]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.