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MAX dimerization protein 4
Symbols MXD4 ; MAD4; MST149; MSTP149; bHLHc12
External IDs MGI104991 HomoloGene4712 GeneCards: MXD4 Gene
RNA expression pattern
PBB GE MXD4 212346 s at tn.png
PBB GE MXD4 210778 s at tn.png
PBB GE MXD4 212347 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10608 17122
Ensembl ENSG00000123933 ENSMUSG00000037235
UniProt Q14582 Q60948
RefSeq (mRNA) NM_006454 NM_010753
RefSeq (protein) NP_006445 NP_034883
Location (UCSC) Chr 4:
2.25 – 2.26 Mb
Chr 5:
34.17 – 34.19 Mb
PubMed search [1] [2]

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[1][2]

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[2]


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.