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Aliases MXRA5, matrix remodeling associated 5
External IDs HomoloGene: 56704 GeneCards: MXRA5
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 3.31 – 3.35 Mb n/a
PubMed search [1] n/a
View/Edit Human

Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.[2]


This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.[2]

Clinical relevance[edit]

Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ a b "Entrez Gene: Matrix-remodelling associated 5". Retrieved 2012-07-24. 
  3. ^ Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M (Sep 2012). "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients". Carcinogenesis. 33 (9): 1797–805. PMID 22696596. doi:10.1093/carcin/bgs210. 

Further reading[edit]

  • Chondrogianni N, de C M Simoes D, Franceschi C, Gonos ES (2004). "Cloning of differentially expressed genes in skin fibroblasts from centenarians". Biogerontology. 5 (6): 401–9. PMID 15609104. doi:10.1007/s10522-004-3188-1. 
  • Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (Jul 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. PMID 15203218. doi:10.1016/j.ygeno.2004.01.011. 
  • Zou TT, Selaru FM, Xu Y, Shustova V, Yin J, Mori Y, Shibata D, Sato F, Wang S, Olaru A, Deacu E, Liu TC, Abraham JM, Meltzer SJ (Jul 2002). "Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon". Oncogene. 21 (31): 4855–62. PMID 12101425. doi:10.1038/sj.onc.1205613. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.