MYB (gene)

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MYB
Protein MYB PDB 1guu.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
External IDsMGI: 97249 HomoloGene: 31311 GeneCards: MYB
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for MYB
Genomic location for MYB
Band6q23.3Start135,181,308 bp[1]
End135,219,173 bp[1]
RNA expression pattern
PBB GE MYB 204798 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198914
NM_010848
NM_033597

RefSeq (protein)

NP_001185843
NP_034978

Location (UCSC)Chr 6: 135.18 – 135.22 MbChr 10: 21.12 – 21.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb-related protein B and Myb proto-oncogene like 1.[5][6]

Function[edit]

Animals[edit]

Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression.

Plants[edit]

MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain.[7]

In maize, phlobaphenes are synthesized in the flavonoids synthetic pathway[8] from polymerisation of flavan-4-ols[9][10] which encodes an R2R3 myb-like transcriptional activator[11] of the A1 gene encoding for the dihydroflavonol 4-reductase (reducing dihydroflavonols into flavan-4-ols)[12] while another gene (Suppressor of Pericarp Pigmentation 1 or SPP1) acts as a suppressor.[13] The maize P gene encodes a Myb homolog that recognizes the sequence CCT/AACC, in sharp contrast with the C/TAACGG bound by vertebrate Myb proteins.[14]

In sorghum, the corresponding yellow seed 1 gene (y1)[15] also encodes a R2R3 type of Myb domain protein that regulates the expression of chalcone synthase, chalcone isomerase and dihydroflavonol reductase genes required for the biosynthesis of 3-deoxyflavonoids.[16]

Ruby is a MYB transcriptional activator of genes that produce anthocyanin in citrus fruits. In most citrus varieties Ruby is non-functional, but in blood oranges it upregulates anthocyanin production to produce the characteristic red color of the fruit.[17]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118513 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019982 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys Res Commun. 360 (2): 433–6. doi:10.1016/j.bbrc.2007.06.078. PMID 17599807.
  6. ^ "Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)".
  7. ^ Stracke R, Werber M, Weisshaar B (October 2001). "The R2R3-MYB gene family in Arabidopsis thaliana". Curr. Opin. Plant Biol. 4 (5): 447–56. doi:10.1016/s1369-5266(00)00199-0. PMID 11597504.
  8. ^ Himi E, Mares DJ, Yanagisawa A, Noda K (July 2002). "Effect of grain colour gene (R) on grain dormancy and sensitivity of the embryo to abscisic acid (ABA) in wheat". J. Exp. Bot. 53 (374): 1569–74. doi:10.1093/jxb/erf005. PMID 12096095.
  9. ^ Winkel-Shirley B (June 2001). "Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology". Plant Physiol. 126 (2): 485–93. doi:10.1104/pp.126.2.485. PMC 1540115. PMID 11402179.
  10. ^ Chopra S, Cocciolone SM, Bushman S, Sangar V, McMullen MD, Peterson T (March 2003). "The maize unstable factor for orange1 is a dominant epigenetic modifier of a tissue specifically silent allele of pericarp color1". Genetics. 163 (3): 1135–46. PMC 1462483. PMID 12663550.
  11. ^ Structural And Transcriptional Analysis Of The Complex P1-wr Cluster In Maize. Wolfgang Goettel, Joachim Messing. Plant & Animal Genomes XVI Conference Archived 2012-02-18 at the Wayback Machine
  12. ^ Dong X, Braun EL, Grotewold E (September 2001). "Functional conservation of plant secondary metabolic enzymes revealed by complementation of Arabidopsis flavonoid mutants with maize genes" (PDF). Plant Physiol. 127 (1): 46–57. doi:10.1104/pp.127.1.46. PMC 117961. PMID 11553733.
  13. ^ Lee EA, Harper V (2002). "Suppressor of Pericarp Pigmentation 1 (SPP1), a novel gene involved in phlobaphene accumulation in maize (Zea mays L.) pericarps". Maydica. 47 (1): 51–58. INIST:13772300
  14. ^ The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset. Erich Grotewold, Bruce J. Drummond, Ben Bowen and Thomas Peterson, Cell, 11 February 199, Volume 76, Issue 3, pages 543-554, doi:10.1016/0092-8674(94)90117-1 PMID 8313474
  15. ^ Boddu J, Svabek C, Ibraheem F, Jones AD, Chopra S (2005). "Characterization of a deletion allele of a sorghum Myb gene yellow seedl showing loss of 3-deoxyflavonoids". Plant Science. 169 (3): 542–552. doi:10.1016/j.plantsci.2005.05.007. INIST:16983977
  16. ^ Boddu J, Jiang C, Sangar V, Olson T, Peterson T, Chopra S (January 2006). "Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis". Plant Mol. Biol. 60 (2): 185–99. doi:10.1007/s11103-005-3568-1. PMID 16429259.
  17. ^ Butelli E, Licciardello C, Zhang Y, Liu J, Mackay S, Bailey P, Reforgiato-Recupero G, Martin C (2012). "Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges". Plant Cell. 24 (3): 1242–55. doi:10.1105/tpc.111.095232. PMC 3336134. PMID 22427337.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.