MYCL1

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MYCL
Identifiers
Aliases MYCL, LMYC, MYCL1, bHLHe38, L-Myc, v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
External IDs MGI: 96799 HomoloGene: 3921 GeneCards: 4610
RNA expression pattern
PBB GE MYCL1 214058 at tn.png

PBB GE MYCL1 215491 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005376
NM_001033081
NM_001033082

NM_008506
NM_001303121

RefSeq (protein)

NP_001028253.1
NP_001028254.2
NP_005367.2

NP_001290050.1
NP_032532.1

Location (UCSC) Chr 1: 39.9 – 39.9 Mb Chr 4: 123 – 123 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[1][2]

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[3]

Interactions[edit]

MYCL1 has been shown to interact with MAX.[4][5]

References[edit]

  1. ^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772. 
  2. ^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)". 
  3. ^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. 
  4. ^ Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science 251 (4998): 1211–1217. doi:10.1126/science.2006410. PMID 2006410. 
  5. ^ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.