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Protein MYH1 PDB 1m8q.png
Aliases MYH1, HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x, myosin, heavy chain 1, skeletal muscle, adult, myosin heavy chain 1
External IDs MGI: 1339711 HomoloGene: 133718 GeneCards: MYH1
RNA expression pattern
PBB GE MYH1 205951 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 10.49 – 10.52 Mb Chr 11: 67.2 – 67.22 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene.[3][4] This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.


Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Class II Myosins are hexameric proteins composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, but rarely in non-muscle cells. These isoforms show expression that is spatially and temporally regulated during development.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Leinwand LA, Saez L, McNally E, Nadal-Ginard B (June 1983). "Isolation and characterization of human myosin heavy chain genes". Proceedings of the National Academy of Sciences of the United States of America. 80 (12): 3716–20. PMC 394121Freely accessible. PMID 6304733. doi:10.1073/pnas.80.12.3716. 
  4. ^ a b "Entrez Gene: MYH1 myosin, heavy chain 1, skeletal muscle, adult". 

Further reading[edit]