MYH1

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MYH1
Protein MYH1 PDB 1m8q.png
Identifiers
AliasesMYH1, HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x, myosin, heavy chain 1, skeletal muscle, adult, myosin heavy chain 1
External IDsMGI: 1339711 HomoloGene: 133718 GeneCards: MYH1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MYH1
Genomic location for MYH1
Band17p13.1Start10,492,307 bp[1]
End10,518,542 bp[1]
RNA expression pattern
PBB GE MYH1 205951 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005963

NM_030679

RefSeq (protein)

NP_005954

NP_109604

Location (UCSC)Chr 17: 10.49 – 10.52 MbChr 11: 67.2 – 67.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene.[5][6] This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.

Function[edit]

Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Class II Myosins are hexameric proteins composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, but rarely in non-muscle cells. These isoforms show expression that is spatially and temporally regulated during development.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109061 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056328 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Leinwand LA, Saez L, McNally E, Nadal-Ginard B (June 1983). "Isolation and characterization of human myosin heavy chain genes". Proceedings of the National Academy of Sciences of the United States of America. 80 (12): 3716–20. doi:10.1073/pnas.80.12.3716. PMC 394121. PMID 6304733.
  6. ^ a b "Entrez Gene: MYH1 myosin, heavy chain 1, skeletal muscle, adult".

Further reading[edit]