MYH14

From Wikipedia, the free encyclopedia
Jump to: navigation, search
MYH14
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MYH14, DFNA4, DFNA4A, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin, FP17425, myosin, heavy chain 14, non-muscle
External IDs MGI: 1919210 HomoloGene: 23480 GeneCards: 79784
RNA expression pattern
PBB GE MYH14 217545 at tn.png

PBB GE MYH14 217660 at tn.png

PBB GE MYH14 219946 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077186
NM_001145809
NM_024729

NM_001271538
NM_001271540
NM_028021

RefSeq (protein)

NP_001070654.1
NP_001139281.1
NP_079005.3

NP_001258467.1
NP_001258469.1
NP_082297.1

Location (UCSC) Chr 19: 50.19 – 50.31 Mb Chr 7: 44.61 – 44.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.[1][2][3]

This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

References[edit]

  1. ^ Leal A, Endele S, Stengel C, Huehne K, Loetterle J, Barrantes R, Winterpacht A, Rautenstrauss B (Aug 2003). "A novel myosin heavy chain gene in human chromosome 19q13.3". Gene 312: 165–71. doi:10.1016/S0378-1119(03)00613-9. PMID 12909352. 
  2. ^ Donaudy F, Snoeckx R, Pfister M, Zenner HP, Blin N, Di Stazio M, Ferrara A, Lanzara C, Ficarella R, Declau F, Pusch CM, Nurnberg P, Melchionda S, Zelante L, Ballana E, Estivill X, Van Camp G, Gasparini P, Savoia A (Mar 2004). "Nonmuscle Myosin Heavy-Chain Gene MYH14 Is Expressed in Cochlea and Mutated in Patients Affected by Autosomal Dominant Hearing Impairment (DFNA4)". Am J Hum Genet 74 (4): 770–6. doi:10.1086/383285. PMC 1181955. PMID 15015131. 
  3. ^ a b "Entrez Gene: MYH14 myosin, heavy chain 14". 

Further reading[edit]

External links[edit]