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Myosin, heavy chain 3, skeletal muscle, embryonic
External IDs OMIM160720 MGI1339709 HomoloGene20553 GeneCards: MYH3 Gene
RNA expression pattern
PBB GE MYH3 205940 at tn.png
More reference expression data
Species Human Mouse
Entrez 4621 17883
Ensembl ENSG00000109063 ENSMUSG00000020908
UniProt P11055 P13541
RefSeq (mRNA) NM_002470 NM_001099635
RefSeq (protein) NP_002461 NP_001093105
Location (UCSC) Chr 17:
10.63 – 10.66 Mb
Chr 11:
67.08 – 67.1 Mb
PubMed search [1] [2]

Myosin-3 is a protein that in humans is encoded by the MYH3 gene.[1][2]


Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes,[3] Freeman-Sheldon syndrome and Sheldon-Hall syndrome.[2]


  1. ^ Eller M, Stedman HH, Sylvester JE, Fertels SH, Rubinstein NA, Kelly AM, Sarkar S (May 1989). "Nucleotide sequence of full length human embryonic myosin heavy chain cDNA". Nucleic Acids Research 17 (9): 3591–2. doi:10.1093/nar/17.9.3591. PMC 317805. PMID 2726495. 
  2. ^ a b "Entrez Gene: MYH3 myosin, heavy chain 3, skeletal muscle, embryonic". 
  3. ^ Alvarado DM, Buchan JG, Gurnett CA, Dobbs MB (Jun 2011). "Exome sequencing identifies an MYH3 mutation in a family with distal arthrogryposis type 1". The Journal of Bone and Joint Surgery. American Volume 93 (11): 1045–50. doi:10.2106/JBJS.J.02004. PMC 3102311. PMID 21531865. 

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