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Myosin, light chain 6, alkali, smooth muscle and non-muscle
PBB Protein MYH11 image.jpg
PDB rendering based on 1br1.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MYL6 ; ESMLC; LC17; LC17-GI; LC17-NM; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM
External IDs OMIM609931 MGI109318 HomoloGene69080 GeneCards: MYL6 Gene
RNA expression pattern
PBB GE MYL6 212082 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4637 17904
Ensembl ENSG00000092841 ENSMUSG00000090841
UniProt P60660 Q60605
RefSeq (mRNA) NM_021019 NM_010860
RefSeq (protein) NP_066299 NP_034990
Location (UCSC) Chr 12:
56.55 – 56.56 Mb
Chr 10:
128.49 – 128.49 Mb
PubMed search [1] [2]

Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.[1][2][3][4]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.[4]


  1. ^ Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG (Jun 1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA". Genomics 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229. 
  2. ^ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol 10 (3): 1095–104. PMC 360973. PMID 2304459. 
  3. ^ Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways". J Biol Chem 264 (15): 9009–15. PMID 2722814. 
  4. ^ a b "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle". 

Further reading[edit]