MYL6

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MYL6
Identifiers
Aliases MYL6, ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM, myosin light chain 6
External IDs MGI: 109318 HomoloGene: 69080 GeneCards: MYL6
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for MYL6
Genomic location for MYL6
Band 12q13.2 Start 56,158,161 bp[1]
End 56,163,496 bp[1]
RNA expression pattern
PBB GE MYL6 212082 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_079425
NM_021019
NM_079423

NM_010860
NM_001317217
NM_001317218
NM_001317219
NM_001317220

RefSeq (protein)

NP_066299
NP_524147

NP_001304146
NP_001304147
NP_001304148
NP_001304149
NP_034990

Location (UCSC) Chr 12: 56.16 – 56.16 Mb Chr 10: 128.49 – 128.49 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.[5][6][7][8]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092841 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090841 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG (Jun 1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA". Genomics. 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229. 
  6. ^ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. PMC 360973Freely accessible. PMID 2304459. 
  7. ^ Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways". J Biol Chem. 264 (15): 9009–15. PMID 2722814. 
  8. ^ a b "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle". 

Further reading[edit]