MYLIP

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MYLIP
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDs MGI: 2388271 HomoloGene: 8309 GeneCards: MYLIP
RNA expression pattern
PBB GE MYLIP 220319 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013262

NM_153789

RefSeq (protein)

NP_037394

NP_722484.2
NP_722484

Location (UCSC) Chr 6: 16.13 – 16.15 Mb Chr 13: 45.39 – 45.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[3]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.[4][5] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.[6] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function[edit]

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein". 
  4. ^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. doi:10.1126/science.1168974. PMC 2777523Freely accessible. PMID 19520913. 
  5. ^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294. 
  6. ^ Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. 

Further reading[edit]