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Myosin regulatory light chain interacting protein
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM610082 MGI2388271 HomoloGene8309 GeneCards: MYLIP Gene
EC number 6.3.2.-
RNA expression pattern
PBB GE MYLIP 220319 s at tn.png
More reference expression data
Species Human Mouse
Entrez 29116 218203
Ensembl ENSG00000007944 ENSMUSG00000038175
UniProt Q8WY64 Q8BM54
RefSeq (mRNA) NM_013262 NM_153789
RefSeq (protein) NP_037394 NP_722484
Location (UCSC) Chr 6:
16.13 – 16.15 Mb
Chr 13:
45.39 – 45.41 Mb
PubMed search [1] [2]

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[1]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.[2][3] The expression of IDOL is induced by the sterol-ativated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol. [4] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.


The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[1]


  1. ^ a b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein". 
  2. ^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science 325 (5936): 100–4. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913. 
  3. ^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294. 
  4. ^ Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. 

Further reading[edit]