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Available structures
PDB Ortholog search: PDBe RCSB
Aliases MYLIP, IDOL, MIR, myosin regulatory light chain interacting protein
External IDs MGI: 2388271 HomoloGene: 8309 GeneCards: MYLIP
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for MYLIP
Genomic location for MYLIP
Band 6p22.3 Start 16,129,125 bp[1]
End 16,148,248 bp[1]
RNA expression pattern
PBB GE MYLIP 220319 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 16.13 – 16.15 Mb Chr 13: 45.39 – 45.41 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[5]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.[6][7] The expression of IDOL is induced by the sterol-activated liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.[8] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.


The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007944 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038175 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein". 
  6. ^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science. 325 (5936): 100–4. doi:10.1126/science.1168974. PMC 2777523Freely accessible. PMID 19520913. 
  7. ^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294. 
  8. ^ Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin. Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. 

Further reading[edit]