MYLK

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MYLK
Protein MYLK PDB 2cqv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK, myosin light chain kinase
External IDs MGI: 894806 HomoloGene: 14202 GeneCards: 4638
RNA expression pattern
PBB GE MYLK 202555 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139300

RefSeq (protein)

n/a

Location (UCSC) Chr 3: 123.61 – 123.88 Mb Chr 16: 34.75 – 35 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.[1]

Function[edit]

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.[2]

See also[edit]

References[edit]

  1. ^ Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG (Mar 1996). "The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21". Genomics 29 (3): 562–70. doi:10.1006/geno.1995.9965. PMID 8575746. 
  2. ^ "Entrez Gene: MYLK myosin, light chain kinase". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.